Champions
Kadokawa Sakura Knights
2nd
Sega Sammy Phoenix
3rd
Shibuya Abemas
5th
Konami Mahjong Fight Club
5th
EX Furinkazan
6th
U-Next Pirates
7th
Akasaka Drivens
8th
Team Raiden
Timeline
- June 25, 2021: Maehara Yudai and Fujisaki Satoshi are dropped by the Konami Mahjong Fight Club
- June 26, 2021: Wakutsu Akira is dropped by the Sega Sammy Phoenix
- July 1, 2021: Takizawa Kazunori leaves the EX Furinkazan
- August 2, 2021: 5 players are drafted in the M-League 2021 Draft
- August 18, 2021: All contracts are signed, confirming 32 players for the M-League 2021-22 Season
- September 10, 2021: New uniforms for the 2021-22 Season created by Mizuno are revealed
- September 13, 2021: M-League 2021-22 schedules are released
- October 4, 2021: M-League 2021-22 Regular Season begins
- November 18, 2021: Date Arisa wins a game with a score of 105,500, being the first player to win with a score over 100,000 and breaking the record of the highest score in M-League history
- December 2, 2021: Asakura Koushin wins a game with a score of 102,400, being only the second player in M-League history to win with a score over 100,000
- March 11, 2022: M-League 2021-22 Regular Season ends
- March 21, 2022: M-League 2021-22 Semifinals begin
- April 8, 2022: M-League 2021-22 Semifinals end
- April 18, 2022: M-League 2021-22 Finals begin
- April 26, 2022: M-League 2021-22 Finals end with the Kadokawa Sakura Knights winning the championship
Draft
1st
2nd
3rd
4th
5th
6th
Standings
Regular Season
| Team | Score |
| U-Next Pirates | +377.1 |
| Shibuya Abemas | +328.2 |
| Konami Mahjong Fight Club | +249.0 |
| EX Furinkazan | +184.4 |
| Sega Sammy Phoenix | +184.2 |
| Kadokawa Sakura Knights | +177.0 |
| Akasaka Drivens | -263.8 |
| Team Raiden | -1256.1 |
Semifinals
| Team | Score |
| Kadokawa Sakura Knights | +248.5 |
| Konami Mahjong Fight Club | +184.9 |
| Shibuya Abemas | +123.9 |
| Sega Sammy Phoenix | +120.2 |
| EX Furinkazan | +68.1 |
| U-Next Pirates | +4.4 |
Finals
| Team | Score |
| Kadokawa Sakura Knights | +202.0 |
| Sega Sammy Phoenix | +141.6 |
| Shibuya Abemas | +54.2 |
| Konami Mahjong Fight Club | -58.9 |
Stats
See @mleague_results tweet, Wikipedia and m-league.jp for expanded results
Yakuman
| Date | Player | Type | Round | Dealer? | Link |
| March 22, 2022 | Sasaki Hisato | Suuankou | S1-1 | Yes | Link |
M-League Watch 